Assorted citrus fruits on a plate - a great source of flavonoids such as quercetin for a healthy diet.

Quercetin & its Healing Properties

Introduction

Quercetin is a flavonoid, a type of phytonutrient found in many fruits, vegetables, and grains. It has been shown to have various positive effects on human health. In this article, we will review the scientific evidence on the beneficial effects of quercetin.

Anti-inflammatory Properties

Quercetin has been shown to have anti-inflammatory properties, which may be beneficial in treating various inflammatory conditions such as arthritis, asthma, and allergies (1). It has been demonstrated that quercetin can inhibit the production of molecules like cytokines and prostaglandins that cause inflammation (2). Additionally, quercetin can suppress the activation of immune cells involved in inflammation (3).

Cardiovascular Health

Quercetin has also been shown to have positive effects on cardiovascular health. It can lower blood pressure and improve blood vessel function, reducing the risk of heart disease (4). A study on overweight and obese individuals found that taking quercetin supplements for 12 weeks significantly lowered blood pressure (5). Additionally, quercetin can decrease LDL cholesterol levels, a risk factor for heart disease (6).

Antioxidant properties

Quercetin is a potent antioxidant that can protect cells from damage caused by free radicals. Oxidative stress is associated with various chronic diseases such as cancer, Alzheimer's, and diabetes (7). Quercetin has been shown to protect cells from oxidative damage in laboratory studies (8). Additionally, quercetin can increase the activity of other antioxidants like glutathione and superoxide dismutase (9).

Brain Health

Quercetin may also have positive effects on brain health. It has been shown to increase cognitive function and memory in animal studies (10). Additionally, quercetin can reduce inflammation in the brain, which contributes to the development of neurodegenerative diseases such as Alzheimer's disease (11).

Immune System

Quercetin may also have positive effects on the immune system. It has been shown to enhance the activity of immune cells, such as natural killer cells and T cells (12). Additionally, quercetin can inhibit the replication of viruses and potentially reduce the severity of viral infections (13).

Conclusion

Quercetin is a flavonoid with various positive effects on human health. It has anti-inflammatory properties, improves cardiovascular health, acts as an antioxidant, promotes brain health, and enhances the immune system. Incorporating foods rich in quercetin, such as apples, berries, onions, and kale, into the diet can provide these health benefits. Alternatively, quercetin supplements can also be used to achieve therapeutic levels of quercetin. 

References:

  1. Rogerio AP, et al. Anti-inflammatory effect of quercetin-loaded microemulsion in the airways allergic inflammatory model in mice. Pharmacol Res. 2010;61(4):288-297. https://doi.org/10.1016/j.phrs.2009.11.002
  2. Kim HP, et al. Inhibition of cyclooxygenase-2 and inducible nitric oxide synthase by luteolin, a flavonoid. Planta Med. 2000;66(4):331-334. https://doi.org/10.1055/s-2000-8614
  3. Di Carlo G, et al. Inhibition of lymphocyte activation by flavonoids. Gen Pharmacol. 1996;27(1):147-150. https://doi.org/10.1016/0306-3623(95)02116-3
  4. Egert S, et al. Quercetin reduces systolic blood pressure and plasma oxidised low-density lipoprotein concentrations in overweight subjects with a high-cardiovascular disease risk phenotype: a double-blinded, placebo-controlled cross-over study. Br J Nutr. 2009;102(7):1065-1074. https://doi.org/10.1017/S0007114509371778
  5. Edwards RL, et al. Quercetin reduces blood pressure in hypertensive subjects. J Nutr. 2007;137(11):2405-2411. https://doi.org/10.1093/jn/137.11.2405
  6. Egert S, et al. Regular consumption of a quercetin-containing supplement improves cardio-metabolic parameters in healthy overweight subjects: a double-blind, randomized, placebo-controlled cross-over study. Nutr J. 2009;8:4. https://doi.org/10.1186/1475-2891-8-4
  7. Valko M, et al. Free radicals and antioxidants in normal physiological functions and human disease. Int J Biochem Cell Biol. 2007;39(1):44-84. https://doi.org/10.1016/j.biocel.2006.07.001
  8. Formica JV, Regelson W. Review of the biology of Quercetin and related bioflavonoids. Food Chem Toxicol. 1995;33(12):1061-1080. https://doi.org/10.1016/0278-6915(95)00077-1
  9. Terao J. Antioxidant activity of quercetin and its inhibition of lipid peroxidation in vitro. Methods Enzymol. 2001;335:406-415. https://doi.org/10.1016/S0076-6879(01)35273-3
  10. Heo HJ, Lee CY. Protective effects of quercetin and vitamin C against oxidative stress-induced neurodegeneration. J Agric Food Chem. 2004;52(25):7514-7517. https://doi.org/10.1021/jf0491141
  11. Sharma M, Gupta YK. Chronic treatment with trans resveratrol prevents intracerebroventricular streptozotocin induced cognitive impairment and oxidative stress in rats. Life Sci. 2002;71(21):2489-2498. https://doi.org/10.1016/S0024-3205(02)02010-3
  12. Li Y, Yao J, Han C, et al. Quercetin, Inflammation and Immunity. Nutrients. 2016;8(3):167. https://doi.org/10.3390/nu8030167
  13. Chen Y, Yao J, Zhang J, et al. Flavonoids, inflammation and immunity. Inflammopharmacology. 2018;26(5): 1145-1161. https://doi.org/10.1007/s10787-018-0518-x
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