Introduction
Resveratrol is a natural polyphenol found in several plants including grapes, berries, and peanuts. Its potential health benefits have garnered attention in recent years, with research suggesting that it may have anti-inflammatory, antioxidant, and anti-cancer properties (1,2).
Anti-Inflammatory Effects
Chronic inflammation is associated with several chronic diseases including heart disease, diabetes, and cancer. Resveratrol has been shown to have anti-inflammatory effects in animal and human studies (3,4).
Antioxidant Effects
Oxidative stress takes place when there are imbalances between reactive oxygen species (ROS) production and the body's ability to neutralize them. This condition can lead to cellular damage and is associated with several chronic diseases. Resveratrol has been found to have antioxidant effects by scavenging ROS and enhancing the activity of antioxidant enzymes in animal and human studies (5,6).
Anti-Cancer Effects
Resveratrol has been shown to have potential anti-cancer effects by inhibiting the growth and proliferation of cancer cells in vitro and in vivo. Additionally, it may have chemopreventive effects by reducing oxidative stress and inflammation, which are risk factors for cancer development (2,7).
Cardiovascular Effects
Resveratrol has been found to have potential cardioprotective effects by reducing inflammation, oxidative stress, and improving lipid metabolism. Studies have also suggested that it may have anti-thrombotic and anti-hypertensive effects, which are risk factors for cardiovascular disease (8,9).
Conclusion
In conclusion, resveratrol has potential health benefits due to its anti-inflammatory, antioxidant, anti-cancer, and cardioprotective effects.
References:
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- Tili E, Michaille J-J, Resveratrol, a pleiotropic molecule targeting inflammation, cancer and viral infections. Oncotarget. 2018;9(2):2262-2282. doi: 10.18632/oncotarget.23119. https://www.oncotarget.com/article/23119/text/
- Shan T, Ma Q, Guo K, et al. Antioxidant capacity of resveratrol: A review of in vitro studies. Behav Pharmacol. 2018;29(6-7):599-609. doi: 10.1097/FBP.0000000000000425. https://journals.lww.com/behaviouralpharm/Fulltext/2018/12000/Antioxidant_capacity_of_resveratrol__a_review_of.3.aspx
- Shankar S, Singh G, Srivastava RK. Chemoprevention by resveratrol: molecular mechanisms and therapeutic potential. Front Biosci. 2007;12:4839-4854. doi: 10.2741/2466. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2453175/
- Delmas D, Jannin B, Latruffe N. Resveratrol: Preventing properties against vascular alterations and ageing. Mol Nutr Food Res. 2005;49(5):377-395. doi: 10.1002/mnfr.200400098. https://onlinelibrary.wiley.com/doi/abs/10.1002/mnfr.200400098
- Singh UP, Singh NP, Singh B, et al. Resveratrol (trans-3,5,4'-trihydroxystilbene) induces silent mating type information regulation-1 and down-regulates nuclear transcription factor-κB activation to abrogate. Mol Pharmacol. 2007;72(6):1466-1476. doi: 10.1124/mol.107.039818. https://molpharm.aspetjournals.org/content/72/6/1466
- Howells LM, Berry DP, Elliott PJ, et al. Phase I randomized, double-blind pilot study of micronized resveratrol (SRT501) in patients with hepatic metastases--safety, pharmacokinetics, and pharmacodynamics. Cancer Prev Res (Phila). 2011;4(9):1419-1425. doi: 10.1158/1940-6207.CAPR-11-0229. https://cancerpreventionresearch.aacrjournals.org/content/4/9/1419.long
- Baur JA, Sinclair DA. Therapeutic potential of resveratrol: the in vivo evidence. Nat Rev Drug Discov. 2006;5(6):493-506. doi: 10.1038/nrd2060. https://www.nature.com/articles/nrd2060
- Kumar A, Kaur H, Devi P, Mohan V. Role of resveratrol in prevention and therapy of cancer: preclinical and clinical studies. Anticancer Agents Med Chem. 2018;18(9):1260-1271. doi: 10.2174/1871520618666180510145808. https://www.ncbi.nlm.nih.gov/pubmed/29737245