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General Health

Organic Elderberry

Organic Elderberry

$39.95 USD
$39.95 USD
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  • 60 Capsules
  • Serving Size - 2 Capsules
  • 300mg Elderberry + 9 Immune Boosting Ingredients/Serving
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Experience the power of our Organic Elderberry formula, expertly blended with immune-boosting ingredients like Vitamin C, Turmeric, Zinc, and Garlic. Elevate your immune health with this potent and comprehensive supplement. Lab Rat prioritizes quality, ensuring our products are third-party tested for purity, and GMP and NSF certified, meeting the highest standards in the industry.

Formula Purposes & Benefits

Purposes

  • Offer a comprehensive immune support supplement
  • Ensure product quality for improved overall health
  • Provide a high standard of manufacturing and testing
  • Offer a high end supplement tested and formulated with premium ingredients for optimal results

Benefits

  • Enhanced immune system function
  • Improved digestive and cardiovascular health
  • Healthier skin and increased energy production

Formula Ingredients & Benefits

Vitamin C

  • Supports immune, cardiovascular, skin, cognitive, fat-burning, and digestive health (2,3).
  • Supports immune health via increased oxidant, free radical scavenging, and fueling neutrophilic (immune cell) activity in chemotaxis, phagocytosis, and microbial killing (2,3).
  • Supports fat burning by increasing carnitine biosynthesis (molecule required for mitochondrial fatty acid oxidation) (2,3).
  • Supports accelerate bone healing after a fracture, increases type I collagen synthesis, and reduces oxidative stress (inflammation) (3).

Vitamin E

  • Supports immune function, cognitive health, cardiovascular health, and bone health (22,23,24,25,26)
  • Supports immune health via neutralizing free radicals and reactive oxygen species, and increased T lymphocyte-mediated immune function (22).
  • Supports cardiovascular health via reduced cholesterol (22).
  • Supports cognitive function via reduced oxidative stress, inflammation, and DNA damage of neuronal tissues (26).

Zinc

  • Supports immune function, skin health, cognitive function, and vision (20,21).
  • Supports the stimulation of the innate and adaptive immune system (20,21).
  • Supports the activation of lymphocytes and activation of innate and T cell-mediated immunity (20,21).
  • Supports cognitive function by modulation of neuronal signaling in areas of the brain associated with memory and learning (hippocampus) (20,21).

L-Glutamine

  • The most abundant amino acid in skeletal muscle that fuels immune cells, improves exercise recovery and optimizes the gut microbiome (1).
  • Vital for lymphocyte (immune cell) proliferation (growth) and paramount in neutrophil (immune cell) destruction of bacteria (1).
  • Vital for activation of genetic signals that support immune function and vitality (1).
  • Glutamine is utilized by immune cells at high rates during catabolic conditions (post-surgery, sepsis, burns, and extreme exercise (1).

Elderberry Extract

  • Supports antioxidant function, cardiovascular health combats respiratory infections, and aids as an antiviral agent (27,28,29,30).
  • Supports antioxidant function due to polyphenolic content, increased free radical scavenging ability, and reduced inflammatory cytokines (27,28,29)
  • May support antiviral activity against pathogens via flavonoids that bind to and prevent H1N1-type IV infection  (40).
  • Supports antimicrobial effects via combating bacteria that cause upper respiratory tract infections (Gram-positive bacteria Streptococcus pyogenes and group C and G Streptococci) (40).

Echinacea

  • Increases antiviral, anti-microbial, antioxidant capacity, and supports a strong immune system (14,15).
  • Supports immune health via decreased impro-inflammatory markers (cytokines IL-6, IL-8, and TNF) (14,15).
  • Supports adaptive and innate immunity via increased monocytes, neutrophils, natural killer cells, and CD8 T cells (14,15).

Garlic

  • Supports cardiovascular health, immune health, joint health, reduced inflammation, gut health, and enhanced antibacterial activity (16).
  • Supports cardiovascular health via reduced hypertension, reduced total cholesterol reduced arterial stiffness (hardening of arteries), and markers of atherosclerosis (16).
  • Supports joint health via reduced NF-κB activation (inflammation) in human fibroblast cells and reduced prevalence of pain in individuals with rheumatoid arthritis (17).
  • Supports gut health via increased prebiotic properties, increased microbiome population, and increased Lactobacillus and Clostridia species (18).
  • Supports immune health via a reduction in inflammatory markers (CRP, TNF, IL-6) (19).

Turmeric 95% curcuminoids

  • Supports antioxidant, cardio-protective, anti-inflammatory, anti-microbial, nephro-protective, hepato-protective, immunomodulatory, and anti-rheumatic effects (13).
  • Reduces inflammation via decreases of inflammatory markers such as c-reactive protein, interleukin 6, tumor necrosis factor, and decreased cytokine production (13).
  • Supports joint health via decreases in connective tissue inflammation and improved pain in individuals with osteoarthritis (12).
  • Supports blood sugar regulation via increased pancreatic beta cell function and improved insulin sensitivity (11).
  • Supports cardiovascular and liver health via reduced accumulation of advanced glycation end products (AGE), reduced lipid peroxidation, and improved vascular function.
  • Curcumin exhibits an antioxidant activity via scavenging of superoxide anion (∙O2−∙) and hydroxyl radicals (∙OH) (scavenging of inflammation molecules) (9,10).
  • Curcumin modulates breast carcinogenesis through its effect on cell cycle and proliferation, apoptosis, senescence, cancer spread and angiogenesis (10).
  • Curcumin targets cancer growth pathways such as the NFkB, PI3K/Akt/mTOR, MAPK and JAK/STAT. thereby suppressing tumor growth (10).

Lactobacillus Acidophilus

  • Supports athletic performance, enhanced gut microbiome, increased muscle mass, immune health, reduced cortisol levels, digestive health, cognitive function, and improved allergy symptoms (4,5,6,7,8).
  • Supports 70% of gut-immunological axis (gut immune system) via enhanced mucosal immune response (toll-like receptors), and upregulation of genetic markers associated with macrophage (gut-immune cell) activity (7,8).
  • Supports digestive and immune health via decreased irritable bowel symptoms, suppression of helicobacter pylori growth (pathogenic bacteria), reduced histamine (reduced allergic response), and reduced gut inflammation (4,5,6,7,8).
  • Supports athletic performance via reduction of respiratory tract infections, reduced muscle damage, improved body composition, reduction lactate induced exercise (muscle burn), and body composition (7).
  • Supports the gut-brain axis via increased neural, endocrine (hormonal), and anti-inflammatory modulation of the hypothalamic-pituitary-adrenal (HPA) axis (7).
  • Reduces inflammation via activation of Toll-like receptors (TLRs) and downregulates the expression of nuclear factor (NF)-κB and pro-inflammatory cytokines (inflammation markers) (8).

Suggested Use: As a dietary supplement take two (2) veggie capsules once a day. For best results take 20-30 minutes before a meal with an 8 oz glass of water, or as directed by your health care professional.

References

References 1-30

  1. Salinas-Casado, J., Esteban-Fuertes, M., Carballido-Rodríguez, J., & Cozar-Olmo, J. M. (2020). Review of the experience and evidence of Pygeum africanum in urological practice. Revisión sobre la experiencia y evidencias del Pygeum africanum en Urología. Actas urologicas espanolas, 44(1), 9–13. https://doi.org/10.1016/j.acuro.2019.08.002
  2. Carr, A. C., & Maggini, S. (2017). Vitamin C and Immune Function. Nutrients, 9(11), 1211. https://doi.org/10.3390/nu9111211
  3. DePhillipo, N. N., Aman, Z. S., Kennedy, M. I., Begley, J. P., Moatshe, G., & LaPrade, R. F. (2018). Efficacy of Vitamin C Supplementation on Collagen Synthesis and Oxidative Stress After Musculoskeletal Injuries: A Systematic Review. Orthopaedic journal of sports medicine, 6(10), 2325967118804544. https://doi.org/10.1177/2325967118804544
  4. Park MS, Kwon B, Ku S, et al: The efficacy of bifidobacterium longum BORI and lactobacillus acidophilus AD031 probiotic treatment in infants with rotavirus infection. Nutrients 2017; 9:pii:E887.
  5. Hungin AP, Mulligan C, Pot B; European Society for Primary Care Gastroenterology, et al: Systematic review: probiotics in the management of lower gastrointestinal symptoms in clinical practice – an evidence-based international guide. Aliment Pharmacol Ther 2013; 38: 864–886.
  6. Velez EM, Maldonado Galdeano C, Carmuega E, et al: Probiotic fermented milk consumption modulates the allergic process induced by ovoalbumin in mice. Br J Nutr 2015; 114: 566–576.
  7. Jäger, R., Mohr, A. E., Carpenter, K. C., Kerksick, C. M., Purpura, M., Moussa, A., Townsend, J. R., Lamprecht, M., West, N. P., Black, K., Gleeson, M., Pyne, D. B., Wells, S. D., Arent, S. M., Smith-Ryan, A. E., Kreider, R. B., Campbell, B. I., Bannock, L., Scheiman, J., Wissent, C. J., … Antonio, J. (2019). International Society of Sports Nutrition Position Stand: Probiotics. Journal of the International Society of Sports Nutrition, 16(1), 62. https://doi.org/10.1186/s12970-019-0329-0
  8. Wilkins, T., & Sequoia, J. (2017). Probiotics for Gastrointestinal Conditions: A Summary of the Evidence. American family physician, 96(3), 170–178.
  9. Barzegar, A., & Moosavi-Movahedi, A. A. (2011). Intracellular ROS protection efficiency and free radical-scavenging activity of curcumin. PloS one, 6(10), e26012. https://doi.org/10.1371/journal.pone.0026012
  10. Banik, U., Parasuraman, S., Adhikary, A. K., & Othman, N. H. (2017). Curcumin: the spicy modulator of breast carcinogenesis. Journal of experimental & clinical cancer research : CR, 36(1), 98. https://doi.org/10.1186/s13046-017-0566-5
  11. Pivari, F., Mingione, A., Brasacchio, C., & Soldati, L. (2019). Curcumin and Type 2 Diabetes Mellitus: Prevention and Treatment. Nutrients, 11(8), 1837. https://doi.org/10.3390/nu11081837
  12. Ashtary-Larky, D., Rezaei Kelishadi, M., Bagheri, R., Moosavian, S. P., Wong, A., Davoodi, S. H., Khalili, P., Dutheil, F., Suzuki, K., & Asbaghi, O. (2021). The Effects of Nano-Curcumin Supplementation on Risk Factors for Cardiovascular Disease: A GRADE-Assessed Systematic Review and Meta-Analysis of Clinical Trials. Antioxidants (Basel, Switzerland), 10(7), 1015. https://doi.org/10.3390/antiox10071015
  13. Mata, I., Mata, S., Menezes, R., Faccioli, L. S., Bandeira, K. K., & Bosco, S. (2020). Benefits of turmeric supplementation for skin health in chronic diseases: a systematic review. Critical reviews in food science and nutrition, 1–15. Advance online publication. https://doi.org/10.1080/10408398.2020.1798353
  14. Aucoin, M., Cardozo, V., McLaren, M. D., Garber, A., Remy, D., Baker, J., Gratton, A., Kala, M. A., Monteiro, S., Warder, C., Perciballi, A., & Cooley, K. (2021). A systematic review on the effects of Echinacea supplementation on cytokine levels: Is there a role in COVID-19?. Metabolism open, 100115. Advance online publication. https://doi.org/10.1016/j.metop.2021.100115
  15. Rondanelli, M., Miccono, A., Lamburghini, S., Avanzato, I., Riva, A., Allegrini, P., Faliva, M. A., Peroni, G., Nichetti, M., & Perna, S. (2018). Self-Care for Common Colds: The Pivotal Role of Vitamin D, Vitamin C, Zinc, and Echinacea in Three Main Immune Interactive Clusters (Physical Barriers, Innate and Adaptive Immunity) Involved during an Episode of Common Colds-Practical Advice on Dosages and on the Time to Take These Nutrients/Botanicals in order to Prevent or Treat Common Colds. Evidence-based complementary and alternative medicine : eCAM, 2018, 5813095. https://doi.org/10.1155/2018/5813095
  16. Varshney, R., & Budoff, M. J. (2016). Garlic and Heart Disease. The Journal of nutrition, 146(2), 416S–421S. https://doi.org/10.3945/jn.114.202333
  17. Fu, E., Tsai, M. C., Chin, Y. T., Tu, H. P., Fu, M. M., Chiang, C. Y., & Chiu, H. C. (2015). The effects of diallyl sulfide upon Porphyromonas gingivalis lipopolysaccharide stimulated proinflammatory cytokine expressions and nuclear factor-kappa B activation in human gingival fibroblasts. Journal of periodontal research, 50(3), 380–388. https://doi.org/10.1111/jre.12217
  18. Ried K. (2020). Garlic lowers blood pressure in hypertensive subjects, improves arterial stiffness and gut microbiota: A review and meta-analysis. Experimental and therapeutic medicine, 19(2), 1472–1478. https://doi.org/10.3892/etm.2019.8374
  19. Darooghegi Mofrad, M., Milajerdi, A., Koohdani, F., Surkan, P. J., & Azadbakht, L. (2019). Garlic Supplementation Reduces Circulating C-reactive Protein, Tumor Necrosis Factor, and Interleukin-6 in Adults: A Systematic Review and Meta-analysis of Randomized Controlled Trials. The Journal of nutrition, 149(4), 605–618. https://doi.org/10.1093/jn/nxy310
  20. Maywald, M., Wessels, I., & Rink, L. (2017). Zinc Signals and Immunity. International journal of molecular sciences, 18(10), 2222. https://doi.org/10.3390/ijms18102222
  21. Wessels, I., Rolles, B., & Rink, L. (2020). The Potential Impact of Zinc Supplementation on COVID-19 Pathogenesis. Frontiers in immunology, 11, 1712. https://doi.org/10.3389/fimmu.2020.01712
  22. Jovic, T. H., Ali, S. R., Ibrahim, N., Jessop, Z. M., Tarassoli, S. P., Dobbs, T. D., Holford, P., Thornton, C. A., & Whitaker, I. S. (2020). Could Vitamins Help in the Fight Against COVID-19?. Nutrients, 12(9), 2550. https://doi.org/10.3390/nu12092550
  23. Traber, M. G., & Atkinson, J. (2007). Vitamin E, antioxidant and nothing more. Free radical biology & medicine, 43(1), 4–15. https://doi.org/10.1016/j.freeradbiomed.2007.03.024
  24. Wu, D., & Meydani, S. N. (2014). Age-associated changes in immune function: impact of vitamin E intervention and the underlying mechanisms. Endocrine, metabolic & immune disorders drug targets, 14(4), 283–289. https://doi.org/10.2174/1871530314666140922143950
  25. De la Fuente, M., Hernanz, A., Guayerbas, N., Victor, V. M., & Arnalich, F. (2008). Vitamin E ingestion improves several immune functions in elderly men and women. Free radical research, 42(3), 272–280. https://doi.org/10.1080/10715760801898838
  26. Browne, D., McGuinness, B., Woodside, J. V., & McKay, G. J. (2019). Vitamin E and Alzheimer's disease: what do we know so far?. Clinical interventions in aging, 14, 1303–1317. https://doi.org/10.2147/CIA.S186760
  27. Ulbricht, C., Basch, E., Cheung, L., Goldberg, H., Hammerness, P., Isaac, R., Khalsa, K. P., Romm, A., Rychlik, I., Varghese, M., Weissner, W., Windsor, R. C., & Wortley, J. (2014). An evidence-based systematic review of elderberry and elderflower (Sambucus nigra) by the Natural Standard Research Collaboration. Journal of dietary supplements, 11(1), 80–120. https://doi.org/10.3109/19390211.2013.859852
  28. Hawkins, J., Baker, C., Cherry, L., & Dunne, E. (2019). Black elderberry (Sambucus nigra) supplementation effectively treats upper respiratory symptoms: A meta-analysis of randomized, controlled clinical trials. Complementary therapies in medicine, 42, 361–365. https://doi.org/10.1016/j.ctim.2018.12.004
  29. Tiralongo, E., Wee, S. S., & Lea, R. A. (2016). Elderberry Supplementation Reduces Cold Duration and Symptoms in Air-Travellers: A Randomized, Double-Blind Placebo-Controlled Clinical Trial. Nutrients, 8(4), 182. https://doi.org/10.3390/nu8040182
  30. Krawitz, C., Mraheil, M. A., Stein, M., Imirzalioglu, C., Domann, E., Pleschka, S., & Hain, T. (2011). Inhibitory activity of a standardized elderberry liquid extract against clinically-relevant human respiratory bacterial pathogens and influenza A and B viruses. BMC complementary and alternative medicine, 11, 16. https://doi.org/10.1186/1472-6882-11-16

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