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Sports Nutrition

Nitric Shock Pre Workout - Lemonade

Nitric Shock Pre Workout - Lemonade

$39.95 USD
$39.95 USD
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  • Servings - 30
  • Serving Size - 1 Rounded Scoop
  • 13 Active Ingredients/Serving
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Experience powerful workouts with our Nitric Shock Pre Workout, expertly formulated to boost energy, focus, and muscle pumps. Enhanced with L-Citrulline for performance and blood flow, this pre-workout won't disrupt sleep and supports muscle growth. Our dedication to quality ensures third-party testing and GMP certification. Elevate your fitness today!

Formula Purposes & Benefits

Purposes

  • Utilize the latest scientific research for formulation
  • Ensure optimal ingredient ratios for maximum results
  • Uphold world-class standards with third-party testing and certifications

Benefits

  • Enhance exercise performance and muscle growth
  • Prevent muscle tissue breakdown and boost energy levels
  • Improve cognition and achieve impressive muscle pumps
  • Experience next-level workouts for better overall health

Formula Ingredients & Benefits

Vitamin B6 pyridoxal 5'-phosphate (PLP)

  • Serves as a cofactor in more than 150 enzymatic reactions associated with blood sugar regulation, immunity, cardiovascular function, neuronal health, metabolic, and digestive health (8,10).
  • Reduces plasma glucose (blood sugar levels) by inhibiting the activity of small-intestinal α-glucosidases (enzymes associated with glucose metabolism) (2).
  • Functions as an antioxidant by counteracting the formation of reactive oxygen species (inflammatory markers) and advanced glycation end-products (8,10).
  • May support blood sugar regulation in women with gestational diabetes (10).
  • Cofactor for enzymes involved in DNA metabolism (10).

Niacin (Vitamin B3)

  • Major B vitamin that supports cardiovascular health by inhibiting hepatic(liver) triglyceride synthesis, reducing very low-density lipoprotein (VLDL) secretion and increasing HDL plasma concentrations (1). 
  • Reduces conversion of VLDL into LDL proteins and serum lipoprotein concentrations in plasma (blood) (1).
  • Vital for regulation of gene expression, cell cycle progression, and DNA repair, and cell death (1).
  • Supports healthy inflammatory response via antioxidant and anti-apoptotic (prevention of cell death) properties (1).
  • Prevents pathologies(diseases) such as Pellagra and reduces the prevalence of nervous anorexia, cancer, and Crohn's disease (2,3).
  • Supports sensitization of tumors to radiation via apoptosis (cell death) cascade of tumor mass and improves oxygen delivery to malignant tissues (cancer cells) (3).
  • Supports cognitive health by reducing the age-related decline of NAD+, increasing quinolinic acid, and reducing neuroinflammation (1).
  • Increased niacin-associated NAD+ levels have been shown to increase neurotransmission, learning, and memory (1).
  • Niacin reduces the prevalence of neurodegenerative pathologies by preventing mitochondrial dysfunction (1).

Caffeine Anhydrous

  • Optimizes energy, cognitive function, and mental alertness (5).
  • Supplementation with caffeine has been shown to acutely enhance exercise performance (5).

L-Citrulline Malate

  • Supports cardiovascular health and exercise performance by increasing the production of l-arginine (6).
  • Increases nitric oxide production, improves exercise performance, and increases blood flow to exercising skeletal muscle (7).
  • Supports strength increases, exercise endurance, and recovery (6,7).
  • May reduce blood pressure by increasing vascular function (6).

Bioperine

  • Increases absorption of amino acids and polyphenols.

Folate (Folic Acid)

  • May support proper cell growth and DNA synthesis (28).

Vitamin B-12 (Methylcobalamin)

  • Metabolically active, methylated form of Vitamin B12 needed for proper DNA synthesis, folate cycle function, energy production, cognitive function, and immune health (15,16).
  • Aids as an antioxidant via direct scavenging of reactive oxygen species (inflammation), preserving l-glutathione levels (master antioxidant), and reducing oxidative stress (15).
  • May prevent vitamin b-12 deficiency diseases such as anemia, neurodegenerative disease, cardiovascular disease, and osteoporosis (16).

Creatine Monohydrate

  • Optimizes exercise performance, muscle mass, strength, thermoregulation, recovery, and intramuscular stores of phosphocreatine (PCr) (47).
  • Vital for the energy reaction of every cell in the human body as a spatial energy shuttle and energy sensor (11,50).
  • Vital in bioenergetics (metabolic activity) of the brain (14).
  • Fuels CD8 and CD4 T- cell-mediated immunity (immune cells) in cancer tissue (12,13).
  • Supports cognition and focus via replenishment of cerebral storage of creatine (creatine in the brain) (14).
  • Supports cognitive health in brain creatine deficiency associated neurodegenerative diseases (14).
  • Supports cognitive health by enhancing the facilitation of synaptic glutamate and neurotransmitter uptake (14).

N-Acetyl Tyrosine

  • Supports memory, cognitive flexibility, executive function of the brain, and convergent thinking (23).
  • Precursor to dopamine and is vital for dopamine synthesis in the brain (23).
  • Supports cognitive function in individuals with high amounts of stress and anxiety (23,24).
  • Increases dopamine levels in highly stressed individuals (23).

Choline Bitrate

  • Essential for cell membrane integrity, cell messaging, fat metabolism, DNA synthesis, immune support, and nervous system function (25,26).
  • Serves as a methyl donor and as a precursor for the production of cell membranes (25).
  • Precursor for acetylcholine (neurotransmitter) which activates receptors in the central nervous system mediated immune responses (α7nAchR) (27).
  • Lifelong choline supplementation may combat neurodegenerative diseases by reducing amyloid-β plaque load (plaques of degrading neurons) (25).
  • Reduces the concentration of total homocysteine (inflammation marker) in individuals with low levels of folate and other B vitamins (B₂, B₆, and B₁₂) (25).

DMAE Bitrate

  • Increases acetylcholine levels in the brain.

L-Theanine

  • Unique non-protein amino acid found in green tea (Camellia sinensis) (17).
  • Supports mood, mental clarity, and cognitive health, memory, and is a natural anti-depressant/neuroprotective agent (17).
  • Aids as an antidepressant due to partial antagonism for the N-methyl-D-aspartate receptor manifesting its cognitive optimizing effects (17).
  • Reduces the neuropsychiatric side effects of chronic adolescent THC exposure (18).

Bacopa Monnieri

  • Supports cognitive function, memory, alertness, and aids as an anti-stress agent (20).
  • May combat inflammatory conditions such as asthma, bronchitis, dropsy, and rheumatism (19,22).
  • Bacopa has been shown to have anti-inflammatory effects on macrophages (immune cells) and inhibits the release of IL-6 and TNF-α (inflammatory markers) from monocytes (immune cells) (21,22).
  • Promising candidate for the development of novel therapeutics that target neuroinflammation and have the potential for treating a wide range of CNS disorders including Alzheimer's disease, depression, and schizophrenia (22).

Suggested Use: Stir 1 rounded scoop with 6-8ounces of cold water and consume 30-45 minutes before beginning activity.

References

References 1-28

  1. Gentilcore D. (2016). Louis Sambon and the Clash of Pellagra Etiologies in Italy and the United States, 1905-14. Journal of the history of medicine and allied sciences, 71(1), 19–42. https://doi.org/10.1093/jhmas/jrv002
  2. Kirkland J. B. (2009). Niacin status and treatment-related leukemogenesis. Molecular cancer therapeutics, 8(4), 725–732. https://doi.org/10.1158/1535-7163.MCT-09-0042
  3. Hoskin, P., Rojas, A., & Saunders, M. (2009). Accelerated radiotherapy, carbogen, and nicotinamide (ARCON) in the treatment of advanced bladder cancer: mature results of a Phase II nonrandomized study. International journal of radiation oncology, biology, physics, 73(5), 1425–1431. https://doi.org/10.1016/j.ijrobp.2008.06.1950
  4. Dording, C. M., Schettler, P. J., Dalton, E. D., Parkin, S. R., Walker, R. S., Fehling, K. B., Fava, M., & Mischoulon, D. (2015). A double-blind placebo-controlled trial of maca root as treatment for antidepressant-induced sexual dysfunction in women. Evidence-based complementary and alternative medicine : eCAM, 2015, 949036. https://doi.org/10.1155/2015/949036
  5. Guest, N. S., VanDusseldorp, T. A., Nelson, M. T., Grgic, J., Schoenfeld, B. J., Jenkins, N., Arent, S. M., Antonio, J., Stout, J. R., Trexler, E. T., Smith-Ryan, A. E., Goldstein, E. R., Kalman, D. S., & Campbell, B. I. (2021). International society of sports nutrition position stand: caffeine and exercise performance. Journal of the International Society of Sports Nutrition, 18(1), 1. https://doi.org/10.1186/s12970-020-00383-4
  6. Figueroa, A., Wong, A., Jaime, S. J., & Gonzales, J. U. (2017). Influence of L-citrulline and watermelon supplementation on vascular function and exercise performance. Current opinion in clinical nutrition and metabolic care, 20(1), 92–98. https://doi.org/10.1097/MCO.0000000000000340
  7. Bahri, S., Zerrouk, N., Aussel, C., Moinard, C., Crenn, P., Curis, E., Chaumeil, J. C., Cynober, L., & Sfar, S. (2013). Citrulline: from metabolism to therapeutic use. Nutrition (Burbank, Los Angeles County, Calif.), 29(3), 479–484. https://doi.org/10.1016/j.nut.2012.07.002
  8. Ueland, P. M., McCann, A., Midttun, Ø., & Ulvik, A. (2017). Inflammation, vitamin B6 and related pathways. Molecular aspects of medicine, 53, 10–27. https://doi.org/10.1016/j.mam.2016.08.001
  9. Bird R. P. (2018). The Emerging Role of Vitamin B6 in Inflammation and Carcinogenesis. Advances in food and nutrition research, 83, 151–194. https://doi.org/10.1016/bs.afnr.2017.11.004
  10. Mascolo, E., & Vernì, F. (2020). Vitamin B6 and Diabetes: Relationship and Molecular Mechanisms. International journal of molecular sciences, 21(10), 3669. https://doi.org/10.3390/ijms21103669
  11. Kreider, R. B., Kalman, D. S., Antonio, J., Ziegenfuss, T. N., Wildman, R., Collins, R., … Lopez, H. L. (2017). International Society of Sports Nutrition position stand: safety and efficacy of creatine supplementation in exercise, sport, and medicine. Journal of the International Society of Sports Nutrition, 14, 18. doi:10.1186/s12970-017-0173-z
  12. Di Biase, S., Ma, X., Wang, X., Yu, J., Wang, Y. C., Smith, D. J., Zhou, Y., Li, Z., Kim, Y. J., Clarke, N., To, A., & Yang, L. (2019). Creatine uptake regulates CD8 T cell antitumor immunity. The Journal of experimental medicine, 216(12), 2869–2882. https://doi.org/10.1084/jem.20182044
  13. Kazak, L., & Cohen, P. (2020). Creatine metabolism: energy homeostasis, immunity and cancer biology. Nature reviews. Endocrinology, 16(8), 421–436. https://doi.org/10.1038/s41574-020-0365-5
  14. Ebrahimi, K., Jourkesh, M., Sadigh-Eteghad, S., Stannard, S. R., Earnest, C. P., Ramsbottom, R., Antonio, J., & Navin, K. H. (2020). Effects of Physical Activity on Brain Energy Biomarkers in Alzheimer's Diseases. Diseases (Basel, Switzerland), 8(2), 18. https://doi.org/10.3390/diseases8020018
  15. van de Lagemaat, E. E., de Groot, L., & van den Heuvel, E. (2019). Vitamin B12in Relation to Oxidative Stress: A Systematic Review. Nutrients, 11(2), 482. https://doi.org/10.3390/nu11020482
  16. Shipton, M. J., & Thachil, J. (2015). Vitamin B12 deficiency - A 21st century perspective . Clinical medicine (London, England), 15(2), 145–150. https://doi.org/10.7861/clinmedicine.15-2-145
  17. Hidese, S., Ogawa, S., Ota, M., Ishida, I., Yasukawa, Z., Ozeki, M., & Kunugi, H. (2019). Effects of L-Theanine Administration on Stress-Related Symptoms and Cognitive Functions in Healthy Adults: A Randomized Controlled Trial. Nutrients, 11(10), 2362. https://doi.org/10.3390/nu11102362
  18. De Felice, M., Renard, J., Hudson, R., Szkudlarek, H. J., Pereira, B. J., Schmid, S., Rushlow, W. J., & Laviolette, S. R. (2021). l-Theanine Prevents Long-Term Affective and Cognitive Side Effects of Adolescent Δ-9-Tetrahydrocannabinol Exposure and Blocks Associated Molecular and Neuronal Abnormalities in the Mesocorticolimbic Circuitry. The Journal of neuroscience : the official journal of the Society for Neuroscience, 41(4), 739–750. https://doi.org/10.1523/JNEUROSCI.1050-20.2020
  19. Nemetchek, M. D., Stierle, A. A., Stierle, D. B., & Lurie, D. I. (2017). The Ayurvedic plant Bacopa monnieri inhibits inflammatory pathways in the brain. Journal of ethnopharmacology, 197, 92–100. https://doi.org/10.1016/j.jep.2016.07.073
  20. Kongkeaw, C., Dilokthornsakul, P., Thanarangsarit, P., Limpeanchob, N., & Norman Scholfield, C. (2014). Meta-analysis of randomized controlled trials on cognitive effects of Bacopa monnieri extract. Journal of ethnopharmacology, 151(1), 528–535. https://doi.org/10.1016/j.jep.2013.11.008
  21. Sukumaran, N. P., Amalraj, A., & Gopi, S. (2019). Neuropharmacological and cognitive effects of Bacopa monnieri (L.) Wettst - A review on its mechanistic aspects. Complementary therapies in medicine, 44, 68–82. https://doi.org/10.1016/j.ctim.2019.03.016
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  25. Velazquez, R., Ferreira, E., Knowles, S., Fux, C., Rodin, A., Winslow, W., & Oddo, S. (2019). Lifelong choline supplementation ameliorates Alzheimer's disease pathology and associated cognitive deficits by attenuating microglia activation. Aging cell, 18(6), e13037. https://doi.org/10.1111/acel.13037
  26. Jadavji, N. M., Emmerson, J. T., MacFarlane, A. J., Willmore, W. G., & Smith, P. D. (2017). B-vitamin and choline supplementation increases neuroplasticity and recovery after stroke. Neurobiology of disease, 103, 89–100. https://doi.org/10.1016/j.nbd.2017.04.001
  27. Jacobson, S. W., Carter, R. C., Molteno, C. D., Stanton, M. E., Herbert, J. S., Lindinger, N. M., Lewis, C. E., Dodge, N. C., Hoyme, H. E., Zeisel, S. H., Meintjes, E. M., Duggan, C. P., & Jacobson, J. L. (2018). Efficacy of Maternal Choline Supplementation During Pregnancy in Mitigating Adverse Effects of Prenatal Alcohol Exposure on Growth and Cognitive Function: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial. Alcoholism, clinical and experimental research, 42(7), 1327–1341. https://doi.org/10.1111/acer.13769
  28. Bailey, L. B., Stover, P. J., McNulty, H., Fenech, M. F., Gregory, J. F., 3rd, Mills, J. L., Pfeiffer, C. M., Fazili, Z., Zhang, M., Ueland, P. M., Molloy, A. M., Caudill, M. A., Shane, B., Berry, R. J., Bailey, R. L., Hausman, D. B., Raghavan, R., & Raiten, D. J. (2015). Biomarkers of Nutrition for Development-Folate Review. The Journal of nutrition, 145(7), 1636S–1680S. https://doi.org/10.3945/jn.114.206599

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